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請使用永久網址來引用或連結此文件:
http://163.15.40.127/ir/handle/987654321/882
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| 題名: | The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-d-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection |
| 作者: | Yang, Chien-Min;Cheng, Hua-Yew;曾華友;Lin, Ta-Chen;Chiang, Lien-Chai;Lin, Chun-Ching;(東方技術學院化妝品應用與管理系) |
| 貢獻者: | 化妝品應用與管理系 |
| 關鍵詞: | Anti-HSV activity;Phyllanthus urinaria;Geraniin;1,3,4,6-tetra-O-galloyl-β-d-glucose |
| 日期: | 2007-04-04 |
| 上傳時間: | 2010-06-09 14:51:48 (UTC+8) |
| 摘要: | Phyllanthus urinaria Linnea (Euphorbiaceae) is a widely used traditional medicinal plant by oriental countries and has been reported to possess various biological activities. Previously, the acetone extract from Phyllanthus urinaria was found to inhibit herpes simplex virus (HSV) infection. In this study, geraniin and 1,3,4,6-tetra-O-galloyl-β-d-glucose (1346TOGDG), both of which were isolated from the acetone extract of Phyllanthus urinaria, were examined for their activity against HSV-1 and HSV-2 in vitro. Results showed that geraniin actively suppressed HSV-2 infection, whereas 1346TOGDG effectively inhibited HSV-1 infection. The 50% inhibitory concentration (IC50) was 18.4 ± 2.0 μM for geraniin against HSV-2 infection, and 19.2 ± 4.0 μM for 1346TOGDG against HSV-1. No toxic effect towards the host cell was observed at the antiviral concentrations. In conclusion, geraniin and 1346TOGDG were found to inhibit HSV-1 and HSV-2 multiplication at different magnitudes of potency. |
| 關聯: | Journal of Ethnopharmacology, Vol.110 no.3, pp.555-558 |
| 顯示於類別: | [時尚美妝設計系] 會議論文
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