In vitro anti-HSV-2 activity and mechanism of action of proanthocyanidin A-1 from Vaccinium vitis-idaea

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題名:	In vitro anti-HSV-2 activity and mechanism of action of proanthocyanidin A-1 from Vaccinium vitis-idaea
作者:	曾華友;Cheng, Hua-Yew;Lin, Ta-Chen;Yang, Chien-Min;Shieh, Den-En;Lin, Chun-Ching;(東方技術學院化妝品應用與管理系)
貢獻者:	東方技術學院化妝品應用與管理系
關鍵詞:	Vaccinium vitis-idaea Linn;lingonberry;proanthocyanidin A-1;anti-HSV-2 activity
日期:	2005
上傳時間:	2009-11-30 15:42:18 (UTC+8)
摘要:	The aim of this study was to investigate the in vitro anti-HSV-2 activity and mechanism of action of proanthocyanidin A-1, a compound isolated from Vaccinium vitis-idaea Linn (Ericaceae). The results demonstrated that proanthocyanidin A-1 exhibited anti-HSV-2 activity. The IC50 value for the XTT assay was 73.3 ± 14.5 µM and the IC50 and IC90 values for the plaque reduction assay were 41.9 ± 2.0 and 62.8 ± 6.3 µM respectively. Proanthocyanidin A-1 showed no cell cytotoxic effect at concentrations that blocked HSV-2 infection, with a CC50 value of 282.1 ± 27.5 µM. The mechanism studies demonstrated that proanthocyanidin A-1 did not reduce viral infectivity but inhibited viral attachment and penetration and affected the late stage(s) of HSV-2 infection. It was concluded that proanthocyanidin A-1 suppressed HSV-2 infection through many modes of action and thus merits further investigation. Copyright © 2004 Society of Chemical Industry
關聯:	Journal of the science of food and agriculture , Vol.85 no.1, pp.10-15
顯示於類別:	[時尚美妝設計系] 期刊論文

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